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KMID : 1123920080220051270
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 5 p.1270 ~ p.1275
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Effects of Polysaccharide Fraction from Euonymus alatus Sieb on T-, B-Lymphocytes and Macrophages in Mice
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Kang Jae-Woo
Shin Ji-Seop
Bang Jun-Sung
Jang Sung-Hoon
Lee Ri-Hua
Jeon Hoon
Kim Dae-Keun
Oh Chan-Ho
Cho Hyoung-Kwon
Eun Jae-Soon
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Abstract
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Effects of polysaccharide fraction from Euonymus alatus Sieb(EPF) on the immune response of T-, B-lymphocytes and macrophages were examined in vitro and in vivo system. EPF (500 mg/kg) were administered p.o. twice a day for 5 days to C57BL/6 mice, and then the cells were separated from mice. EPF decreased the viability of thymocytes, but increased the viability of splenocytes in vitro and in vivo system. Also, the administration of EPF enhanced the population of helper T cell and cytotoxic T cell in thymocytes and did not affect the population of splenocytes. Furthermore, EPF enhanced the phagocytic activity and the production of nitric oxide in peritoneal macro phages in vivo system. These results suggest that EPF regulates an immune response via the enhancement of mature T lymphocytes and B lymphocytes viability and phagocytic activity of macrophages.
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KEYWORD
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Euonymus alatus Sieb(EPF), thymocytes, splenocytes, macrophages
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